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KMID : 0378019770200070087
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New Medical Journal
1977 Volume.20 No. 7 p.87 ~ p.92
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Effects of a Combination of Diphenylhydantoin and Chlorpromazine on Thought, Affect and Behavior of Schizophrenics
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兪桂濬/Yoo, Kae Joon
梁元淑/金種柱/Yang, Won Sook/Kim, Jong Joo
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Abstract
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The present study investigated the effects of a combined treatment of diphenylhydantoin and chlorpromazine on thought, affect and behavior of schizophrenic patients, comparing with chlorpromazine and placebo as a double-blind study.
The number of patients selected for this study were 22 hospitalized patients.
They were 5 acute schizophrenic episodes, 1 schizoaffective, 10 paranoid type and 6 chronic undifferentiated type which they showed rather acutely vivid symptoms, even though they were all relapsed and readmitted.
Patients were randomly divided to two groups of D. P. H. +C. P. Z, and C. P. Z. +Placebo.
Daily recommended dosages were 300mg for D. P. H, and between 150mg and 600mg for C. P. Z.
They were all received drugs orally for two weeks for the study. Using the psychiatric rating scale and psychological testings (Rorschach and Korean Wechsler Intelligence Scale), the authors applied them to the before and after medication, and obtained the following results.
1) On the hyperside of psychopathology in the affect and behavior such as irritability, excitability, hyperactivity, hostility and anger etc, it seemed that the combination of two drugs have statistically significance to compare with C. P. Z. only, and totally they showed the trends of reducing the symptoms deviated from normality at the end of two weeks. But on the hyposide of it such as depression and hypoactivity etc, they showed little effect, both.
2) On thought process and content of thought, the two groups showed statistically no significance at the end of two weeks.
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